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. 2005;19(3):147-51.
doi: 10.1159/000083247. Epub 2005 Jan 11.

Ethnic differences in cerebral venous thrombosis

Erica Cristina Sá de Camargo  1 , Ayrton Roberto Massaro, Luiz Alberto Bacheschi, Elbio Antônio D'Amico, Paula Ribeiro Villaça, Rogério Pastore Bassitt, Sandra Fátima Gualandro, Israel Bendit, Milberto Scaff
Affiliations

Ethnic differences in cerebral venous thrombosis

Erica Cristina Sá de Camargo et al. Cerebrovasc Dis. 2005.

Abstract

Background: Cerebral venous thromboses (CVT) with distinct clinical presentations have been shown worldwide. However, there is little information regarding race-ethnic differences in this disease.

Methods: We prospectively studied 50 CVT patients from Brazil, comparing clinical and laboratory data among white (W) and African-Brazilian (AB) patients.

Results: Seventy percent of the patients were female, 26 W and 23 AB, mean age 34.7 years. Multiple sinus CVT, deep CVT and worse outcome were significantly more frequent in AB than in W patients. There was a trend towards a higher frequency of factor V Leiden and prothrombin mutation in W than in AB, and of protein C deficiency in AB.

Conclusions: CVT was more severe in AB patients than in W patients. Race-ethnic differences may account for the heterogeneous distribution of inherited thrombophilia in this series.

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