Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1992 Mar;55(3):209-11.
doi: 10.1136/jnnp.55.3.209.

Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin

W J Triggs  1 , C R Roe, W J Rhead, S K Hanson, S N Lin, L J Willmore
Affiliations
Case Reports

Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin

W J Triggs et al. J Neurol Neurosurg Psychiatry. 1992 Mar.

Abstract

A 29 year old woman is described with severe hyperemesis gravidarum, atypical migraine, numerous admissions to hospital for psychiatric illness, non-epileptic seizures, and valproate-induced coma. Metabolic studies and measurement of [9,10(n)-3H]palmitate oxidation by cultured fibroblasts suggested a multiple acyl-CoA dehydrogenation disorder. Treatment with riboflavin abolished headaches and abnormal behaviour and normalised the plasma free carnitine level. Subtle defects in mitochondrial beta oxidation may be a treatable cause of disordered behaviour in adults.

PubMed Disclaimer

References

    1. N Engl J Med. 1979 Dec 27;301(26):1405-9 - PubMed
    1. J Biol Chem. 1978 Apr 25;253(8):2688-93 - PubMed
    1. Arch Neurol. 1990 Oct;47(10):1131-3 - PubMed
    1. Neurology. 1990 Mar;40(3 Pt 1):487-91 - PubMed
    1. Pediatr Res. 1990 Mar;27(3):311-5 - PubMed

Publication types

MeSH terms