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Comment
. 2005 Jan 18;102(3):519-20.
doi: 10.1073/pnas.0408858102. Epub 2005 Jan 12.

Accessorizing natural products: adding to nature's toolbox

Sherry S Lamb  1 , Gerard D Wright
Affiliations
Comment

Accessorizing natural products: adding to nature's toolbox

Sherry S Lamb et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Diversity of natural products by means of biocombinatorial chemistry. Initially, biochemical modification of a scaffold results in a small number of structurally distinct compounds (C1, C2, and C3), followed by the production of more complex and unique compounds (C1a, C1b, C1c, etc.).
Fig. 2.
Fig. 2.
Nature's tools for scaffold modification. (A) Accessorizing the glycopeptide antibiotic scaffold results in a variety of antibiotics with different properties. (B) Glycosylation of the enterobactin scaffold generates more efficient siderophores, namely salmochelins.
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References

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