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Review
. 2005 Jan;11(1):17-22.
doi: 10.1016/j.molmed.2004.11.008.

Medulloblastoma: developmental mechanisms out of control

Silvia Marino  1
Affiliations
Review

Medulloblastoma: developmental mechanisms out of control

Silvia Marino. Trends Mol Med. 2005 Jan.

Abstract

Medulloblastoma, which is a highly aggressive central nervous system neoplasm, represents an intriguing example of how deregulated developmental mechanisms can lead to tumour development. Recent advances in the understanding of the role of Sonic Hedgehog, Wnt and Notch signalling pathways in the development of the cerebellum have shed new light on medulloblastoma pathogenesis.

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