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. 1979 May;95(2):329-46.

Delay in growth and the development of nephritis in rats treated with interferon preparations in the neonatal period

I Gresser, L Morel-Maroger, F Châtelet, C Maury, M Tovey, M T Bandu, J Buywid, M Delauche

Delay in growth and the development of nephritis in rats treated with interferon preparations in the neonatal period

I Gresser et al. Am J Pathol. 1979 May.

Abstract

Suckling rats were injected for 14 to 17 days with potent rat-cell-culture interferon preparations or various heterologous interferon or control preparations. Only treatment with rat interferon resulted in a delay in growth and maturation of different organs and the subsequent development of an "immune complex" type nephritis. Thus, 38 of 43 rats treated with rat interferon developed a severe glomerulonephritis. Thus, 38 of 43 rats treated with rat interferon developed a severe glomerulonephritis, whereas only 3 of 99 rats in the various control groups had minimal renal lesions. Deposits of IgG and C3 along the glomerular basement membrane were only seen in interferon-treated rats.

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