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. 2005 Feb;241(2):208-16.
doi: 10.1097/01.sla.0000151794.28392.a6.

High incidence of thrombosis of the portal venous system after laparoscopic splenectomy: a prospective study with contrast-enhanced CT scan

Masataka Ikeda  1 , Mitsugu Sekimoto, Shuji Takiguchi, Masaru Kubota, Masakazu Ikenaga, Hirofumi Yamamoto, Yoshiyuki Fujiwara, Masayuki Ohue, Takushi Yasuda, Hiroshi Imamura, Masayuki Tatsuta, Masahiko Yano, Hiroshi Furukawa, Morito Monden
Affiliations

High incidence of thrombosis of the portal venous system after laparoscopic splenectomy: a prospective study with contrast-enhanced CT scan

Masataka Ikeda et al. Ann Surg. 2005 Feb.

Abstract

Objective: The aims of this prospective study were to investigate the true incidence of portal or splenic vein thrombosis (PSVT) after elective laparoscopic splenectomy using contrast-enhanced computed tomography (CT) scan, and outcome of anticoagulant therapy for PSVT.

Summary background data: Although rare, thrombosis of the portal venous system is considered a possible cause of death after splenectomy. The reported incidence of ultrasonographically detected PSVT after elective open splenectomy ranges from 6.3% to 10%.

Methods: Twenty-two patients underwent laparoscopic splenectomy (LS group), and 21 patients underwent open splenectomy (OS group). Preoperative and postoperative helical CT with contrast were obtained in all patients, and the extent of thrombosis was investigated. Prothrombotic disorder was also determined.

Results: PSVT occurred in 12 (55%) patients of the LS group, but in only 4 (19%) of the OS group. The difference was significant (P = 0.03). Clinical symptoms appeared in 4 of the 12 LS patients. Thrombosis occurred in the intrahepatic portal vein (n = 9), extrahepatic portal vein (n = 2), mesenteric veins (n = 1), proximal splenic vein (n = 4), and distal splenic vein (n = 8). Prothrombotic disorder was diagnosed in 1 patient. Anticoagulant therapy was initiated once the diagnosis was established, and complete recanalization, except for distal splenic vein, was observed without any adverse event. Patients with splenomegaly were at high risk of PSVT.

Conclusions: PSVT is a more frequent complication of laparoscopic splenectomy than previously reported but can be treated safely following early detection by CT with contrast.

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Figures

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FIGURE 1. Schematic drawing of portal and splenic vein thrombosis (PSVT) after laparoscopic splenectomy (LS). Numbers in parentheses indicate days after operation.
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FIGURE 2. Schematic drawing of portal or splenic vein thrombosis (PSVT) after open splenectomy (OS). Numbers in parentheses indicate days after operation.
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FIGURE 3. Sequential changes in preoperative and postoperative platelet counts, white blood cell counts, and C-reactive protein (CRP). Values are mean ± SEM.
See this image and copyright information in PMC

Comment in

  • Much remains to be learned.
    Eubanks S. Eubanks S. Ann Surg. 2005 Feb;241(2):217-8. doi: 10.1097/01.sla.0000152108.66049.87. Ann Surg. 2005. PMID: 15650629 Free PMC article. No abstract available.
  • Problem of portal venous thrombosis after splenectomy.
    Winslow ER, Klingensmith ME, Brunt LM. Winslow ER, et al. Ann Surg. 2005 Nov;242(5):745; author reply 745-6. doi: 10.1097/01.sla.0000187687.64275.9b. Ann Surg. 2005. PMID: 16244551 Free PMC article. No abstract available.

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