Review
doi: 10.1152/physiol.00048.2004.
A role for the Wilms' tumor protein WT1 in organ development
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- PMID: 15653840
- DOI: 10.1152/physiol.00048.2004
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Review
A role for the Wilms' tumor protein WT1 in organ development
Physiology (Bethesda).
2005 Feb.
Free article
Abstract
Wilms' tumor (nephroblastoma) represents a unique example of an aberrant kidney formation that can result from mutations in a tumor suppressor gene, Wilms' tumor 1 (WT1). Targeted gene inactivation in mice testifies that WT1 is a master switch for the development of the genitourinary system and other organs.
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