Review
doi: 10.1152/physiol.00042.2004.
Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions
Affiliations
- PMID: 15653842
- DOI: 10.1152/physiol.00042.2004
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Review
Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions
Physiology (Bethesda).
2005 Feb.
Free article
Abstract
Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.
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