B-raf and a B-raf pseudogene are located on 7q in man
- PMID: 1565476
B-raf and a B-raf pseudogene are located on 7q in man
Abstract
The B-raf gene was localized to human chromosome region 7p11-7qter by Southern blot analysis of its segregation in a panel of rodent-human hybrids, using a B-raf cDNA clone. Chromosomal in situ hybridization refined the localization to 7q33-36. Analysis of genomic B-raf clones identified a B-raf pseudogene in addition to the active gene. Based on the chromosomal mapping data we conclude that the pseudogene is located near the active gene.
Similar articles
-
Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.Oncogene. 1992 Aug;7(8):1657-60. Oncogene. 1992. PMID: 1630826
-
Genomic organization and nucleotide sequence of the coding region of the chicken c-Rmil(B-raf-1) proto-oncogene.Biochem Biophys Res Commun. 1993 Jun 30;193(3):1324-31. doi: 10.1006/bbrc.1993.1770. Biochem Biophys Res Commun. 1993. PMID: 8323553
-
Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.Genomics. 1997 Aug 15;44(1):83-93. doi: 10.1006/geno.1997.4855. Genomics. 1997. PMID: 9286703
-
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.Oncogene. 1990 Dec;5(12):1775-80. Oncogene. 1990. PMID: 2284096 Review.
-
raf oncogenes in carcinogenesis.Crit Rev Oncog. 1990;2(1):1-8. Crit Rev Oncog. 1990. PMID: 2091747 Review.
Cited by
-
Evaluation of the expression levels of BRAFV600E mRNA in primary tumors of thyroid cancer using an ultrasensitive mutation assay.BMC Cancer. 2020 May 1;20(1):368. doi: 10.1186/s12885-020-06862-w. BMC Cancer. 2020. PMID: 32357861 Free PMC article.
-
Absence of BRAF mutation in pheochromocytoma and paraganglioma.Neoplasma. 2017;64(2):278-282. doi: 10.4149/neo_2017_215. Neoplasma. 2017. PMID: 28043156 Free PMC article.
-
Role of Pseudogenes in Tumorigenesis.Cancers (Basel). 2018 Aug 1;10(8):256. doi: 10.3390/cancers10080256. Cancers (Basel). 2018. PMID: 30071685 Free PMC article. Review.
-
1H and 31P Magnetic Resonance Spectroscopic Metabolomic Imaging: Assessing Mitogen-Activated Protein Kinase Inhibition in Melanoma.Cells. 2024 Jul 19;13(14):1220. doi: 10.3390/cells13141220. Cells. 2024. PMID: 39056801 Free PMC article.
-
A Software Tool for Reagent Design to Expand Access to Single-Nucleotide Variant Detection by the Oligonucleotide Ligation Assay.J Mol Diagn. 2025 Mar;27(3):184-198. doi: 10.1016/j.jmoldx.2024.12.007. Epub 2025 Jan 14. J Mol Diagn. 2025. PMID: 39818318 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous