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. 2005 Feb 15;191(4):499-502.
doi: 10.1086/428291. Epub 2005 Jan 14.

Association between a novel human coronavirus and Kawasaki disease

Frank Esper  1 , Eugene D Shapiro, Carla Weibel, David Ferguson, Marie L Landry, Jeffrey S Kahn
Affiliations

Association between a novel human coronavirus and Kawasaki disease

Frank Esper et al. J Infect Dis. .

Abstract

Kawasaki disease is a systemic vasculitis of childhood; its etiology is unknown. We identified evidence of a novel human coronavirus, designated "New Haven coronavirus" (HCoV-NH), in respiratory secretions from a 6-month-old infant with classic Kawasaki disease. To further investigate the possible association between HCoV-NH infection and Kawasaki disease, we conducted a case-control study. Specimens of respiratory secretions from 8 (72.7%) of 11 children with Kawasaki disease and from 1 (4.5%) of 22 control subjects (children without Kawasaki disease matched by age and the time the specimens were obtained) tested positive for HCoV-NH by reverse-transcriptase polymerase chain reaction (Mantel-Haenszel matched odds ratio, 16.0 [95% confidence interval, 3.4-74.4]; P=.0015). These data suggest that HCoV-NH infection is associated with Kawasaki disease.

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Comment in

  • Coronaviruses in the limelight.
    McIntosh K. McIntosh K. J Infect Dis. 2005 Feb 15;191(4):489-91. doi: 10.1086/428510. Epub 2005 Jan 14. J Infect Dis. 2005. PMID: 15655769 Free PMC article. No abstract available.
  • Lack of association between New Haven coronavirus and Kawasaki disease.
    Ebihara T, Endo R, Ma X, Ishiguro N, Kikuta H. Ebihara T, et al. J Infect Dis. 2005 Jul 15;192(2):351-2; author reply 353. doi: 10.1086/430797. J Infect Dis. 2005. PMID: 15962233 Free PMC article. No abstract available.
  • Kawasaki disease and human coronavirus.
    Belay ED, Erdman DD, Anderson LJ, Peret TC, Schrag SJ, Fields BS, Burns JC, Schonberger LB. Belay ED, et al. J Infect Dis. 2005 Jul 15;192(2):352-3; author reply 353. doi: 10.1086/431609. J Infect Dis. 2005. PMID: 15962234 Free PMC article. No abstract available.

References

    1. Rowley AH, Shulman ST. Kawasaki syndrome. Pediatr Clin North Am. 1999;46:313–29. - PubMed
    1. American Academy of Pediatrics. 2000 red book: report of the Committee on Infectious Diseases, 25th ed., 2000. Elk Grove Village, IL: American Academy of Pediatrics;
    1. Rosenfeld EA, Corydon KE, Shulman ST. Kawasaki disease in infants less than one year of age. J Pediatr. 1995;126:524–9. - PubMed
    1. Yanagawa H, Nakamura Y, Kawasaki T, Shigematsu I. Nationwide epidemic of Kawasaki disease in Japan during winter of 1985–86. Lancet. 1986;2:1138–9. - PubMed
    1. Bell DM, Brink EW, Nitzkin JL, et al. Kawasaki syndrome: description of two outbreaks in the United States. N Engl J Med. 1981;304:1568–75. - PubMed

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