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Comparative Study
. 1992 Apr 15;89(8):3630-4.
doi: 10.1073/pnas.89.8.3630.

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

R L Weinshank  1 , J M Zgombick, M J Macchi, T A Branchek, P R Hartig
Affiliations
Comparative Study

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

R L Weinshank et al. Proc Natl Acad Sci U S A. .

Abstract

The serotonin 1D (5-HT1D) receptor is a pharmacologically defined binding site and functional receptor site. Observed variations in the properties of 5-HT1D receptors in different tissues have led to the speculation that multiple receptor proteins with slightly different properties may exist. We report here the cloning, deduced amino acid sequences, pharmacological properties, and second-messenger coupling of a pair of human 5-HT1D receptor genes, which we have designated 5-HT1D alpha and 5-HT1D beta due to their strong similarities in sequence, pharmacological properties, and second-messenger coupling. Both genes are free of introns in their coding regions, are expressed in the human cerebral cortex, and can couple to inhibition of adenylate cyclase activity. The pharmacological binding properties of these two human receptors are very similar, and match closely the pharmacological properties of human, bovine, and guinea pig 5-HT1D sites. Both receptors exhibit high-affinity binding of sumatriptan, a new anti-migraine medication, and thus are candidates for the pharmacological site of action of this drug.

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References

    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Anal Biochem. 1983 Jul 1;132(1):6-13 - PubMed
    1. Mol Pharmacol. 1992 Jan;41(1):1-7 - PubMed
    1. Mol Pharmacol. 1991 Dec;40(6):1036-42 - PubMed
    1. EMBO J. 1991 Dec;10(13):4017-23 - PubMed

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