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. 2005 Jan 17;201(2):169-71.
doi: 10.1084/jem.20042279.

IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

Estelle Bettelli  1 , Vijay K Kuchroo
Affiliations

IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

Estelle Bettelli et al. J Exp Med. .

Abstract

Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23-driven subset of Th cells called Th(IL-17) has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23-induced Th(IL-17) cells are a unique subset or are related to other Th subsets is discussed.

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Figures

Figure 1.
Figure 1.
Hypothetical model of ThIL-17 cell development. IL-23–driven THIL-17 cells may represent a unique subset of Th cells that arises from a novel Th precursor cell. Alternatively, THIL-17 cells may develop from pre–Th1 cells that differentiate into Th1 cells in the presence of IL-12, but THIL-17 cells in the presence of IL-23. Dashed arrows indicate hypothetical pathways of ThIL-17 subset development.
See this image and copyright information in PMC

References

    1. Ho, I.C., and L.H. Glimcher. 2002. Transcription: tantalizing times for T cells. Cell. 109:S109–S120. - PubMed
    1. Murphy, K.M., and S.L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2:933–944. - PubMed
    1. Monney, L., C.A. Sabatos, J.L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E.A. Greenfield, A.J. Coyle, R.A. Sobel, G.J. Freeman, and V.K. Kuchroo. 2002. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 415:536–541. - PubMed
    1. Szabo, S.J., S.T. Kim, G.L. Costa, X. Zhang, C.G. Fathman, and L.H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 100:655–669. - PubMed
    1. Oppmann, B., R. Lesley, B. Blom, J.C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 13:715–725. - PubMed