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Review
. 2004 Dec;18(12):687-90.
doi: 10.1089/apc.2004.18.687.

Rhabdomyolysis after simvastatin therapy in an HIV-infected patient with chronic renal failure

Hiroshi Moro  1 , Hiroki Tsukada, Atsuto Tanuma, Arimasa Shirasaki, Noriaki Iino, Takeaki Nishibori, Shinichi Nishi, Fumitake Gejyo
Affiliations
Review

Rhabdomyolysis after simvastatin therapy in an HIV-infected patient with chronic renal failure

Hiroshi Moro et al. AIDS Patient Care STDS. 2004 Dec.

Abstract

We encountered a 49-year-old HIV-infected man with chronic renal insufficiency who developed rhabdomyolysis after treatment with simvastatin. He recovered after initiating hemodialysis and discontinuing oral medications. Rhabdomyolysis most likely resulted from an excessive blood concentration of simvastatin caused by concomitant use of fluconazole in the presence of renal insufficiency.

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