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. 1992 Apr 17;256(5055):377-9.
doi: 10.1126/science.256.5055.377.

Nucleoid condensation in Escherichia coli that express a chlamydial histone homolog

C E Barry 3rd  1 , S F Hayes, T Hackstadt
Affiliations

Nucleoid condensation in Escherichia coli that express a chlamydial histone homolog

C E Barry 3rd et al. Science. .

Abstract

Chlamydial cell types are adapted for either extracellular survival or intracellular growth. In the transcriptionally inert elementary bodies, the chromosome is densely compacted; in metabolically active reticulate bodies, the chromatin is loosely organized. Condensation of the chlamydial nucleoid occurs concomitant with expression of proteins homologous to eukaryotic histone H1. When the Chlamydia trachomatis 18-kilodalton histone homolog Hc1 is expressed in Escherichia coli, a condensed nucleoid structure similar to that of chlamydiae is observed with both light and electron microscopy. These results support a role for Hc1 in condensation of the chlamydial nucleoid.

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