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. 2005 Mar;29(3):283-6.
doi: 10.1016/j.leukres.2004.07.007.

Expression of IFITM1 in chronic myeloid leukemia patients

Cemaliye Boylu Akyerli  1 , Meral Beksac, Michelle Holko, Mathias Frevel, Klara Dalva, Uğur Ozbek, Ender Soydan, Muhit Ozcan, Gülsüm Ozet, Osman Ilhan, Günhan Gürman, Hamdi Akan, Bryan R G Williams, Tayfun Ozçelik
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Free article

Expression of IFITM1 in chronic myeloid leukemia patients

Cemaliye Boylu Akyerli et al. Leuk Res. 2005 Mar.
Free article

Abstract

We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.

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