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Comparative Study
. 2005 Jan 5;133(1):162-5.
doi: 10.1016/j.molbrainres.2004.09.023.

Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse

Topi Tervonen  1 , Karl Akerman, Ben A Oostra, Maija Castrén
Affiliations
Comparative Study

Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse

Topi Tervonen et al. Brain Res Mol Brain Res. .

Abstract

In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.

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