Review
doi: 10.1016/j.ceb.2004.12.006.
Recent progress in dynein structure and mechanism
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- PMID: 15661525
- DOI: 10.1016/j.ceb.2004.12.006
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Review
Recent progress in dynein structure and mechanism
Curr Opin Cell Biol.
2005 Feb.
Abstract
Dynein is a minus-end-directed microtubule motor crucial to diverse cellular processes. The unwieldy size of the molecule and the difficulty of expressing and purifying mutants have hampered mechanistic studies of dynein. Recent progress sheds light on key unsolved questions concerning how the molecule is really organized, what conformational changes accompany ATP hydrolysis and whether two or three motor domains are coordinated in their motion.
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