doi: 10.1126/science.1104343.
Mitochondrial dysfunction and type 2 diabetes
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- PMID: 15662004
- DOI: 10.1126/science.1104343
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Mitochondrial dysfunction and type 2 diabetes
Science.
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Abstract
Maintenance of normal blood glucose levels depends on a complex interplay between the insulin responsiveness of skeletal muscle and liver and glucose-stimulated insulin secretion by pancreatic beta cells. Defects in the former are responsible for insulin resistance, and defects in the latter are responsible for progression to hyperglycemia. Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction.
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