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. 1992 Jan-Feb;86(1):31-3.
doi: 10.1016/0035-9203(92)90427-e.

Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol

G Antezana  1 , R Zeballos, C Mendoza, P Lyevre, L Valda, F Cardenas, I Noriega, H Ugarte, J P Dedet
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Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol

G Antezana et al. Trans R Soc Trop Med Hyg. 1992 Jan-Feb.

Abstract

The electrocardiographic (ECG) changes in Bolivian patients with mucocutaneous leishmaniasis, treated with meglumine antimoniate and allopurinol, were evaluated. Electric changes due to the antimonial compound appeared in 45% of the patients, and consisted of repolarization alteration, principally affecting the T wave and the S-T segment. The changes disappeared within 2 months following the end of the antimonial treatment. In patients with associated Chagas disease and leishmaniasis, antimonial therapy did not aggravate the ECG changes characteristic of Chagasic cardiopathy.

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