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Review
. 2005 Jan 20;45(2):185-7.
doi: 10.1016/j.neuron.2005.01.006.

The molecular machinery of resurgent sodium current revealed

Bruce P Bean  1
Affiliations
Free article
Review

The molecular machinery of resurgent sodium current revealed

Bruce P Bean. Neuron. .
Free article

Abstract

Some TTX-sensitive sodium channels open transiently during recovery from inactivation, generating a "resurgent" sodium current that flows immediately following action potentials. In this issue of Neuron, Grieco and colleagues present evidence that resurgent sodium current results from a novel form of inactivation in which the cytoplasmic tail of the beta4 subunit acts as a classic open-channel blocker.

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