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. 2004 Oct;138(4):401-3.
doi: 10.1007/s10517-005-0111-y.

Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy

A V Kulikov  1 , M A Tikhonova, V F Chugui, T A Alekhina, V G Kolpakov, N K Popova
Affiliations

Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy

A V Kulikov et al. Bull Exp Biol Med. 2004 Oct.

Abstract

The effects of acute and chronic imipramine treatment on the degree of catalepsy were compared in GC rats genetically predisposed to catalepsy. We recorded the time over which the rats remained in a vertical position they were placed. As differentiated from acute treatment, chronic administration of imipramine dose-dependently decreased the time of freezing in GC rats.

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