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Review
. 2005;65(3):413-32.
doi: 10.2165/00003495-200565030-00006.

Tenofovir disoproxil fumarate: a review of its use in the management of HIV infection

Katherine A Lyseng-Williamson  1 , Neil A Reynolds, Greg L Plosker
Affiliations
Review

Tenofovir disoproxil fumarate: a review of its use in the management of HIV infection

Katherine A Lyseng-Williamson et al. Drugs. 2005.

Abstract

Tenofovir disoproxil fumarate (tenofovir DF; Viread), an ester prodrug of the nucleotide reverse transcriptase inhibitor (NRTI) tenofovir, is indicated in combination with other antiretroviral agents in the treatment of HIV infection. As a component of an antiretroviral regimen, oral tenofovir DF 300 mg once daily effectively reduces viral load in patients with HIV infection who are treatment-experienced with baseline NRTI resistance mutations or treatment-naive. Tenofovir DF provides a simple and convenient once-daily dosage regimen, and is generally well tolerated and able to produce sustained suppression of viral replication.

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