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Clinical Trial
. 2004;31(4):257-9.

Effect of antagonists vs agonists on in vitro fertilization outcome

M L Check  1 , J H Check, J K Choel, E Davies, D Kiefer
Affiliations
  • PMID: 15672958
Clinical Trial

Effect of antagonists vs agonists on in vitro fertilization outcome

M L Check et al. Clin Exp Obstet Gynecol. 2004.

Abstract

Purpose: To compare outcome following in vitro fertilization-embryo transfer (IVF-ET) using controlled ovarian hyperstimulation (COH) regimens using either the gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate vs the GnRH antagonist ganirelix.

Methods: Women needing IVF for conception were randomly assigned to 300 IU of gonadotropins with ganirelix used in the follicular phase when a follicle with a 14 mm average diameter was attained vs a regimen using leuprolide acetate from the mid-luteal phase of the previous cycle.

Results: There were no differences found in clinical, ongoing, delivered pregnancy rates or implantation rates between groups.

Conclusions: The use of GnRH antagonists do not seem to reduce IVF outcome compared to using GnRH agonists in COH regimens.

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