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Comment
. 2005 Feb 1;102(5):1275-6.
doi: 10.1073/pnas.0409587101. Epub 2005 Jan 26.

The ups and downs of gene expression and retroviral DNA integration

Alan Engelman  1
Affiliations
Comment

The ups and downs of gene expression and retroviral DNA integration

Alan Engelman. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Models for promoter/gene targeting during retroviral integration. (A) TFs bound to the promoter region of a hypothetical gene tether PICs for integration into nearby sequences. This general scenario applies to Ty3, where TFIIIB and TFIIIC help target retrotransposition (14). Because MLV preferred promoters and 5′ ends of coding regions (11), such a scheme may apply for this virus. (B) HIV-1 preferred genes to a greater extent than ALV, but both integrated into genes more frequently than nongene regions. In contrast to MLV, integration occurred fairly evenly along genes, which might occur by means of an affinity for the transcription complex itself. The work by Maxfield et al. (2) discounts this model, at least for ALV. (C) Alternatively, PICs might target gene regions by association with an unknown chromatin factor(s) X.
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References

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