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Case Reports
. 2005 Feb;58(2):220-1.
doi: 10.1136/jcp.2004.020685.

Osseous metaplasia in a tubular adenoma of the colon

W I Al-Daraji  1 , A Abdellaoui, W D Salman
Affiliations
Case Reports

Osseous metaplasia in a tubular adenoma of the colon

W I Al-Daraji et al. J Clin Pathol. 2005 Feb.

Abstract

An 85 year old woman presented with a one month history of change in her bowel habits in the form of alternating diarrhoea and constipation. She also noted some rectal bleeding. Flexible sigmoidoscopy revealed a 1.5 cm polyp 30 cm from the anus. The polyp was removed during the sigmoidoscopy by electrocautery and sent for histological examination. The polyp was a tubular adenoma with mild dysplasia. The adenoma contained numerous foci of metaplastic bone. These consisted of irregular islands of mineralised osteoid bone rimmed by a layer of scattered osteoblasts. This is the first case of osseous metaplasia in a tubular adenoma of the colon to be reported.

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Figures

Figure 1
Figure 1
Histopathological appearance of osseous metaplasia in a colonic tubular adenoma. (A) Sections stained with haematoxylin and eosin showing a tubular adenoma with foci of metaplastic bone (original magnification, ×5). (B) Haematoxylin and eosin stained sections showing dysplastic colon glands with focal stromal osseous metaplasia (original magnification, ×20).
See this image and copyright information in PMC

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