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Multicenter Study
. 2005 Mar;36(3):673-5.
doi: 10.1161/01.STR.0000154878.58398.14. Epub 2005 Jan 27.

Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis

Salvatore Novo  1 , Stefania Basili, Rosalba Tantillo, Angela Falco, Valentina Davì, Giuseppina Novo, Egle Corrado, Giovanni Davì
Affiliations
Multicenter Study

Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis

Salvatore Novo et al. Stroke. 2005 Mar.

Abstract

Background and purpose: We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques.

Methods: Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years).

Results: ALCS patients had higher (P<0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (P=0.003) independently predicted cardiovascular risk.

Conclusions: High levels of sCD40L may predict the risk of CV events in ALCS.

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