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Clinical Trial
. 2005 Feb;162(2):386-8.
doi: 10.1176/appi.ajp.162.2.386.

Improved p50 auditory gating with ondansetron in medicated schizophrenia patients

Lawrence E Adler  1 , Ellen M Cawthra, Kara A Donovan, Josette G Harris, Herbert T Nagamoto, Ann Olincy, Merilyne C Waldo
Affiliations
Clinical Trial

Improved p50 auditory gating with ondansetron in medicated schizophrenia patients

Lawrence E Adler et al. Am J Psychiatry. 2005 Feb.

Abstract

Objective: Most schizophrenia patients have a deficit in auditory sensory gating, which appears to be mediated by the alpha-7 nicotinic receptor, that is not improved with conventional antipsychotic treatment. This study examined the effects of ondansetron, a highly selective 5-HT3 antagonist, on the P50 auditory evoked potential.

Method: Eight medicated outpatients with schizophrenia were given either ondansetron (16 mg) or placebo in a double-blind, placebo-controlled design. Evoked potentials were recorded at baseline and 1 hour, 2 hours, and 3 hours after receipt of drug.

Results: There was a highly significant improvement in P50 gating after ondansetron treatment. The maximal treatment difference was at 2 hours posttreatment (ondansetron: mean=41.4%, SD=39.7%; placebo: mean=80.2%, SD=21.3%).

Conclusions: Ondansetron significantly enhanced P50 auditory gating in schizophrenia patients treated with typical antipsychotics.

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