Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Feb;11(2):185-96.
doi: 10.1097/00054725-200502000-00013.

A review of activity indices and end points for clinical trials in children with Crohn's disease

Anne M Griffiths  1 , Anthony R Otley, Jeffrey Hyams, Antonio R Quiros, Richard J Grand, Athos Bousvaros, Brian G Feagan, George R Ferry
Affiliations
Review

A review of activity indices and end points for clinical trials in children with Crohn's disease

Anne M Griffiths et al. Inflamm Bowel Dis. 2005 Feb.

Abstract

The necessity to include children and adolescents in clinical trials is increasingly recognized. Two recent workshops provided the impetus for pediatric gastroenterologists to develop evidence-based recommendations concerning end points and outcome assessment in cases of pediatric Crohn's disease. The overall goal was to facilitate clinical trial design by standardizing the methodology. This article critically reviews the available assessment tools and provides consensus recommendations for the evaluation of linear growth, disease activity, and health-related quality of life in clinical trials in pediatric Crohn's disease.

PubMed Disclaimer

Similar articles

  • Converging goals of treatment of inflammatory bowel disease from clinical trials and practice.
    Levesque BG, Sandborn WJ, Ruel J, Feagan BG, Sands BE, Colombel JF. Levesque BG, et al. Gastroenterology. 2015 Jan;148(1):37-51.e1. doi: 10.1053/j.gastro.2014.08.003. Epub 2014 Aug 13. Gastroenterology. 2015. PMID: 25127678 Review.
  • IOIBD technical review on endoscopic indices for Crohn's disease clinical trials.
    Vuitton L, Marteau P, Sandborn WJ, Levesque BG, Feagan B, Vermeire S, Danese S, D'Haens G, Lowenberg M, Khanna R, Fiorino G, Travis S, Mary JY, Peyrin-Biroulet L. Vuitton L, et al. Gut. 2016 Sep;65(9):1447-55. doi: 10.1136/gutjnl-2015-309903. Epub 2015 Sep 9. Gut. 2016. PMID: 26353983
  • Profile of pediatric Crohn's disease in Belgium.
    De Greef E, Mahachie John JM, Hoffman I, Smets F, Van Biervliet S, Scaillon M, Hauser B, Paquot I, Alliet P, Arts W, Dewit O, Peeters H, Baert F, D'Haens G, Rahier JF, Etienne I, Bauraind O, Van Gossum A, Vermeire S, Fontaine F, Muls V, Louis E, Van de Mierop F, Coche JC, Van Steen K, Veereman G; IBD working group of the Belgian Society of Pediatric Gastroenterology, Hepatology and Nutrition (BeSPGHAN); Belgian IBD Research and Development. De Greef E, et al. J Crohns Colitis. 2013 Dec;7(11):e588-98. doi: 10.1016/j.crohns.2013.04.016. Epub 2013 May 9. J Crohns Colitis. 2013. PMID: 23664896
  • French national consensus clinical guidelines for the management of Crohn's disease.
    Peyrin-Biroulet L, Bouhnik Y, Roblin X, Bonnaud G, Hagège H, Hébuterne X; gastroenterologist nominal group. Peyrin-Biroulet L, et al. Dig Liver Dis. 2017 Apr;49(4):368-377. doi: 10.1016/j.dld.2016.12.008. Epub 2016 Dec 22. Dig Liver Dis. 2017. PMID: 28087156
  • Optimising monitoring in the management of Crohn's disease: a physician's perspective.
    Papay P, Ignjatovic A, Karmiris K, Amarante H, Milheller P, Feagan B, D'Haens G, Marteau P, Reinisch W, Sturm A, Steinwurz F, Egan L, Panés J, Louis E, Colombel JF, Panaccione R. Papay P, et al. J Crohns Colitis. 2013 Sep;7(8):653-69. doi: 10.1016/j.crohns.2013.02.005. Epub 2013 Apr 4. J Crohns Colitis. 2013. PMID: 23562672 Review.
See all similar articles

Cited by

See all "Cited by" articles