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Review
. 2005 Feb;11(2):185-96.
doi: 10.1097/00054725-200502000-00013.

A review of activity indices and end points for clinical trials in children with Crohn's disease

Anne M Griffiths  1 , Anthony R Otley, Jeffrey Hyams, Antonio R Quiros, Richard J Grand, Athos Bousvaros, Brian G Feagan, George R Ferry
Affiliations
Review

A review of activity indices and end points for clinical trials in children with Crohn's disease

Anne M Griffiths et al. Inflamm Bowel Dis. 2005 Feb.

Abstract

The necessity to include children and adolescents in clinical trials is increasingly recognized. Two recent workshops provided the impetus for pediatric gastroenterologists to develop evidence-based recommendations concerning end points and outcome assessment in cases of pediatric Crohn's disease. The overall goal was to facilitate clinical trial design by standardizing the methodology. This article critically reviews the available assessment tools and provides consensus recommendations for the evaluation of linear growth, disease activity, and health-related quality of life in clinical trials in pediatric Crohn's disease.

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