Review
doi: 10.1078/0171-9335-00389.
Keratinocyte growth factor: effects on keratinocytes and mechanisms of action
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- PMID: 15679105
- DOI: 10.1078/0171-9335-00389
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Review
Keratinocyte growth factor: effects on keratinocytes and mechanisms of action
Eur J Cell Biol.
2004 Dec.
Abstract
Keratinocyte growth factor (KGF) is a potent and specific mitogen for different types of epithelial cells, and it can protect these cells from various insults. Due to these properties, it is of particular importance for the repair of injured epithelial tissues, and it is currently therapeutically explored for the treatment of radiation- and chemotherapy-induced mucosal epithelial damage in cancer patients. In this review we summarize the current knowledge on the role of KGF in tissue repair and cytoprotection, and we report on its mechanisms of action in keratinocytes.
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