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Review
. 2005 Feb 7;579(4):904-8.
doi: 10.1016/j.febslet.2004.11.031.

The mammalian Mediator complex

Joan Weliky Conaway  1 , Laurence Florens, Shigeo Sato, Chieri Tomomori-Sato, Tari J Parmely, Tingting Yao, Selene K Swanson, Charles A S Banks, Michael P Washburn, Ronald C Conaway
Affiliations
Free article
Review

The mammalian Mediator complex

Joan Weliky Conaway et al. FEBS Lett. .
Free article

Abstract

The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.

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