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Review
. 2005 Feb 7;579(4):938-42.
doi: 10.1016/j.febslet.2004.11.048.

Recognition and selection of tRNA in translation

Marina V Rodnina  1 , Kirill B Gromadski, Ute Kothe, Hans-Joachim Wieden
Affiliations
Free article
Review

Recognition and selection of tRNA in translation

Marina V Rodnina et al. FEBS Lett. .
Free article

Abstract

Aminoacyl-tRNA (aa-tRNA) is delivered to the ribosome in a ternary complex with elongation factor Tu (EF-Tu) and GTP. The stepwise movement of aa-tRNA from EF-Tu into the ribosomal A site entails a number of intermediates. The ribosome recognizes aa-tRNA through shape discrimination of the codon-anticodon duplex and regulates the rates of GTP hydrolysis by EF-Tu and aa-tRNA accommodation in the A site by an induced fit mechanism. Recent results of kinetic measurements, ribosome crystallography, single molecule FRET measurements, and cryo-electron microscopy suggest the mechanism of tRNA recognition and selection.

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