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Case Reports
. 2004 Dec;19(6):453-5.
doi: 10.2133/dmpk.19.453.

A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy

Kaori Morimoto  1 , Tomoharu Oishi, Shiro Ueda, Madoka Ueda, Masakiyo Hosokawa, Kan Chiba
Affiliations
Free article
Case Reports

A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy

Kaori Morimoto et al. Drug Metab Pharmacokinet. 2004 Dec.
Free article

Abstract

We have recently found that the frequency of OATP-C*15 is significantly higher in patients who experienced myopathy after receiving pravastatin or atorvastatin than in patients without myopathy. However, there were two patients who experienced pravastatin-induced myopathy despite the fact that they did not possess OATP-C*15 or other known mutations of OATP-C that have been reported to decrease the function of OATP-C. In this study, we sequenced all of the exons and exon-intron junctions of OATP-C of the two patients and found a novel mutation in exon 12 of OATP-C in one of the patients. In this mutation (1628T>G), there is a substitution of Leu to Trp at position 543 in transmembrane-spanning domain 10 of OATP-C. However, the frequency of this mutation in the Japanese population appears to be very low (<1%).

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