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. 2005 Feb 1;172(3):323-5.
doi: 10.1503/cmaj.1040945.

Percutaneous coronary intervention and drug-eluting stents

Yi-ming Yang  1 , Issam Moussa
Affiliations

Percutaneous coronary intervention and drug-eluting stents

Yi-ming Yang et al. CMAJ. .
No abstract available

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Figures

None
Figure. Vascular response to balloon angioplasty (top panel), balloon angioplasty plus bare-metal stent (middle panel) and balloon angioplasty plus drug-eluting stent (bottom panel). Top panel: Balloon inflation increases lumen diameter by stretching the media and the adventitia and causes plaque fracture and dissection; the lumen area decreases within days because of elastic recoil, and a thin layer of thrombus covers the lumen and fills the dissection plane; neointimal growth leads to further lumen loss weeks to months after the procedure. Middle panel: A bare-metal stent prevents elastic recoil and seals the dissection flap but causes deeper tissue injury and extensive thrombus formation around the stent struts; exaggerated neointimal formation caused by the stent negates the benefit of its scaffolding effect and results in in-stent restenosis. Bottom panel: A drug-eluting stent not only provides scaffolding to prevent elastic recoil, but the drug contained in the polymer coating of the stent inhibits neointimal proliferation.
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