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Meta-Analysis
. 2005 Feb 14;92(3):430-3.
doi: 10.1038/sj.bjc.6602369.

Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis

A G Renehan  1 , M Egger, M P Saunders, S T O'Dwyer
Affiliations
Meta-Analysis

Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis

A G Renehan et al. Br J Cancer. .

Abstract

A meta-analysis of six randomised trials demonstrated that intensive followup in colorectal cancer was associated with an absolute reduction in all-cause 5-year mortality of 10% (95% confidence interval (CI): 4-16)--however, only two percent (95% CI: 0-5) was attributable to cure from salvage re-operations. We postulate that other factors, such as increased psychological well-being and/or altered lifestyle, and/or improved treatment of coincidental disease may contribute to the remaining lives saved, and form important future research questions.

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Figures

Figure 1
Figure 1
Absolute risk differences for overall lives gained, lives gained through salvage and through factors other than salvage: random-effects method. CI: confidence interval. FU: followup.
See this image and copyright information in PMC

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