Comment
doi: 10.1084/jem.2011fta.
Discovering lymphocyte subsets
Affiliations
- PMID: 15685724
- PMCID: PMC2212771
- DOI: 10.1084/jem.2011fta
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Comment
Discovering lymphocyte subsets
J Exp Med.
.
Abstract
At a scientific meeting in 1968, Jacques Miller was accused of complicating immunology. He and others suggested that there was not one but two kinds of lymphocytes--one from the thymus and one from the bone marrow. In a pair of groundbreaking articles published in the Journal of Experimental Medicine in 1968, Miller and his student Graham Mitchell proved that two subsets of lymphocytes did exist and identified which subset mediated antibody responses.
Figures
Jacques Miller in the laboratory, 1966. Courtesy of the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Comment on
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Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes.J Exp Med. 1968 Oct 1;128(4):801-20. doi: 10.1084/jem.128.4.801. J Exp Med. 1968. PMID: 5691985 Free PMC article.
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Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.J Exp Med. 1968 Oct 1;128(4):821-37. doi: 10.1084/jem.128.4.821. J Exp Med. 1968. PMID: 5691986 Free PMC article.
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References
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