doi: 10.1021/ja044631v.
A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth
Affiliations
- PMID: 15686343
- DOI: 10.1021/ja044631v
Item in Clipboard
A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth
J Am Chem Soc.
.
Abstract
We report a fucose alpha(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucalpha(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucalpha(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.
Similar articles
-
Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):21-6. doi: 10.1073/pnas.0503381102. Epub 2005 Dec 22. Proc Natl Acad Sci U S A. 2006. PMID: 16373512 Free PMC article.
-
Identification of the plasticity-relevant fucose-alpha(1-2)-galactose proteome from the mouse olfactory bulb.Biochemistry. 2009 Aug 4;48(30):7261-70. doi: 10.1021/bi900640x. Biochemistry. 2009. PMID: 19527073 Free PMC article.
-
Identification of fucose alpha(1-2) galactose epitope-containing glycoproteins from rat hippocampus.Neuroreport. 1998 Mar 30;9(5):813-7. doi: 10.1097/00001756-199803300-00009. Neuroreport. 1998. PMID: 9579671
-
The role of galactosyltransferases in cell surface functions and in the immune system.Drug News Perspect. 2006 Sep;19(7):401-9. doi: 10.1358/dnp.2006.19.7.1021491. Drug News Perspect. 2006. PMID: 17080203 Review.
-
Lectin-resistant cell surface variants of eukaryotic cells.Int Rev Cytol. 1982;75:101-65. doi: 10.1016/s0074-7696(08)61003-7. Int Rev Cytol. 1982. PMID: 6213577 Review. No abstract available.
Cited by
-
A spoonful of L-fucose-an efficient therapy for GFUS-CDG, a new glycosylation disorder.EMBO Mol Med. 2021 Sep 7;13(9):e14332. doi: 10.15252/emmm.202114332. Epub 2021 Sep 1. EMBO Mol Med. 2021. PMID: 34468083 Free PMC article.
-
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.PLoS One. 2012;7(2):e30643. doi: 10.1371/journal.pone.0030643. Epub 2012 Feb 17. PLoS One. 2012. PMID: 22363459 Free PMC article.
-
Multicomponent reaction derived small di- and tri-carbohydrate-based glycomimetics as tools for probing lectin specificity.Glycoconj J. 2022 Oct;39(5):587-597. doi: 10.1007/s10719-022-10079-3. Epub 2022 Aug 24. Glycoconj J. 2022. PMID: 36001188
-
A cell-free biosynthesis platform for modular construction of protein glycosylation pathways.Nat Commun. 2019 Nov 27;10(1):5404. doi: 10.1038/s41467-019-12024-9. Nat Commun. 2019. PMID: 31776339 Free PMC article.
-
Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):21-6. doi: 10.1073/pnas.0503381102. Epub 2005 Dec 22. Proc Natl Acad Sci U S A. 2006. PMID: 16373512 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
