doi: 10.1016/j.bmcl.2004.12.031.
Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I
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- PMID: 15686923
- DOI: 10.1016/j.bmcl.2004.12.031
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Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I
Bioorg Med Chem Lett.
.
Abstract
Suppression of resistance to anticancer drugs by COTC of glyoxalase I (GloI) inhibitor targeting intracellular glutathione (GSH) and GloI was studied. Depletion of the cellular GSH content and inhibition of GloI by COTC increased chemotherapy-mediated apoptosis in apoptosis-resistant pancreatic adenocarcinoma AsPC-1 cells.
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