doi: 10.1016/j.tube.2004.08.001.
Epub 2005 Jan 22.
Mouse and guinea pig models for testing new tuberculosis vaccines
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- PMID: 15687022
- DOI: 10.1016/j.tube.2004.08.001
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Mouse and guinea pig models for testing new tuberculosis vaccines
Tuberculosis (Edinb).
2005 Jan-Mar.
Abstract
Animal models of pulmonary tuberculosis in the mouse and guinea pig contain to provide new information about the host response in the lungs, changes in immunopathology, and the protective effect of new vaccine candidates. These include Mtb72F, a polyprotein vaccine that gives excellent protection and also boosts and prolongs the protective effect of the BCG vaccine.
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