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Review
. 2005 Jan;6(1):9-20.
doi: 10.1038/nrm1547.

Function and regulation of cullin-RING ubiquitin ligases

Matthew D Petroski  1 , Raymond J Deshaies
Affiliations
Review

Function and regulation of cullin-RING ubiquitin ligases

Matthew D Petroski et al. Nat Rev Mol Cell Biol. 2005 Jan.

Abstract

Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.

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