Review
doi: 10.1038/nrm1547.
Function and regulation of cullin-RING ubiquitin ligases
Affiliations
- PMID: 15688063
- DOI: 10.1038/nrm1547
Item in Clipboard
Review
Function and regulation of cullin-RING ubiquitin ligases
Nat Rev Mol Cell Biol.
2005 Jan.
Abstract
Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.
Similar articles
-
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.EMBO J. 2013 Aug 28;32(17):2307-20. doi: 10.1038/emboj.2013.173. Epub 2013 Aug 2. EMBO J. 2013. PMID: 23912815 Free PMC article. Review.
-
Dissecting the function of Cullin-RING ubiquitin ligase complex genes in planarian regeneration.Dev Biol. 2018 Jan 15;433(2):210-217. doi: 10.1016/j.ydbio.2017.10.011. Epub 2017 Dec 25. Dev Biol. 2018. PMID: 29291974
-
Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.Subcell Biochem. 2017;83:323-347. doi: 10.1007/978-3-319-46503-6_12. Subcell Biochem. 2017. PMID: 28271482 Free PMC article. Review.
-
Viral modulators of cullin RING ubiquitin ligases: culling the host defense.Sci STKE. 2006 May 16;2006(335):pe21. doi: 10.1126/stke.3352006pe21. Sci STKE. 2006. PMID: 16705129 Review.
-
Immunoprecipitation of Cullin-RING Ligases (CRLs) in Arabidopsis thaliana Seedlings.Methods Mol Biol. 2016;1450:11-21. doi: 10.1007/978-1-4939-3759-2_2. Methods Mol Biol. 2016. PMID: 27424742
Cited by
-
Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.Aging (Albany NY). 2021 Apr 4;13(7):10603-10618. doi: 10.18632/aging.202823. Epub 2021 Apr 4. Aging (Albany NY). 2021. PMID: 33833131 Free PMC article.
-
DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.Mol Cell Biol. 2013 Apr;33(8):1621-31. doi: 10.1128/MCB.01342-12. Epub 2013 Feb 11. Mol Cell Biol. 2013. PMID: 23401859 Free PMC article.
-
Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.mBio. 2015 Jan 27;6(1):e02490-14. doi: 10.1128/mBio.02490-14. mBio. 2015. PMID: 25626907 Free PMC article.
-
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.Nat Commun. 2021 Apr 28;12(1):2461. doi: 10.1038/s41467-021-22941-3. Nat Commun. 2021. PMID: 33911083 Free PMC article.
-
Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy.Int J Biochem Mol Biol. 2012;3(3):273-81. Epub 2012 Sep 25. Int J Biochem Mol Biol. 2012. PMID: 23097743 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
