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Review
. 2005 Jan;6(1):32-43.
doi: 10.1038/nrm1548.

ADAMs: key components in EGFR signalling and development

Carl P Blobel  1
Affiliations
Review

ADAMs: key components in EGFR signalling and development

Carl P Blobel. Nat Rev Mol Cell Biol. 2005 Jan.

Abstract

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.

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