Comment
doi: 10.1016/j.devcel.2005.01.004.
Costal-2: a scaffold for kinases mediates Hedgehog signaling
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- PMID: 15691757
- DOI: 10.1016/j.devcel.2005.01.004
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Comment
Costal-2: a scaffold for kinases mediates Hedgehog signaling
Dev Cell.
2005 Feb.
Free article
Abstract
Drosophila genetics has identified several components of the Hedgehog signaling pathway, but the mechanism by which they act remains elusive. In this issue of Developmental Cell, a report by Zhang et al. provides evidence that the kinesin-related protein Costal-2 forms a multi-component scaffold that mediates Hedgehog signaling.
Comment on
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Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.Dev Cell. 2005 Feb;8(2):267-78. doi: 10.1016/j.devcel.2005.01.001. Dev Cell. 2005. PMID: 15691767
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