Assessment of endothelial dysfunction: focus on atherothrombotic disease

Abstract

As the endothelium is crucial to cardiovascular disease, the accurate assessment of this organ is a valuable tool, especially if such assessments are clinically relevant. As functions of the endothelium focus on haemostasis and the maintenance of correct vascular tone, and dysfunction results in changes that promote thrombosis and hypertension, thus assessment of endothelial function therefore follows these processes. Foremost in the plasma markers of vascular function is von Willebrand factor, a molecule that interacts with platelets. Lack of nitric oxide results in poor blood pressure control that can be quantified by impaired flow mediated dilatation. More recently, increased numbers of circulating endothelial cells have been described that indicate severe damage to the endothelium. Unsurprisingly, these three markers correlate with each other and former two predict adverse outcome in long-term follow up studies. The assessment of vascular damage is becoming recognised as having an increasingly prominent part in the pathophysiology of cardiovascular disease.