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Comparative Study
. 2005 Feb 8;1033(2):216-20.
doi: 10.1016/j.brainres.2004.11.040.

Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP

Jose A Aguirre  1 , Jan Kehr, Takashi Yoshitake, Fang-Ling Liu, Alicia Rivera, Sergio Fernandez-Espinola, Beth Andbjer, Giuseppina Leo, Andrew D Medhurst, Luigi F Agnati, Kjell Fuxe
Affiliations
Comparative Study

Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP

Jose A Aguirre et al. Brain Res. .

Abstract

The mGluR5 antagonist MPEP was used to study the role of mGluR5 in MPTP-induced injury of the nigrostriatal DA neurons. The findings indicate that acute blockade of mGluR5 may result in neuroprotective actions against MPTP neurotoxicity on nigral DA cell bodies and striatal DA terminals using stereological analysis of TH immunoreactivity and microdensitometry. Biochemical analysis showed no restoration of DA levels and metabolism indicating a maintained reduction of DA transmission.

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