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. 2005 Jan;35(1):42-5.
doi: 10.1016/j.medmal.2004.07.032.

[Glucantime injection: benefit versus toxicity]

[Article in French]
A Masmoudi  1 , N Maalej, M Mseddi, A Souissi, H Turki, S Boudaya, S Bouassida, A Zahaf
Affiliations

[Glucantime injection: benefit versus toxicity]

[Article in French]
A Masmoudi et al. Med Mal Infect. 2005 Jan.

Abstract

Glucantime is the most common stibied derivative used to treat cutaneous leishmaniasis (CL) in Tunisia; however adverse effects have been reported.

Objectives: This retrospective study deals with the various adverse of intramuscular glucantime used for CL.

Results: Nineteen patients (21%) receiving intramuscular Glucantime developed adverse effects. 8 male and 11 female patients, mean age 45, ranging from 8 to 84 years were affected. adverse effects were: fever (3), arthralgia and myalgia (4), nausea and vomiting (2), erythema nodosum (1), acute renal failure (3 including 1 lethal case), hepatic cytolysis (1), skin rash (4), and inflammation of the injection site (1).

Conclusion: Adverse effects of intramuscular Glucantime were relatively frequent in our series. Arthralgia, myalgia, and skin rash were not severe and disappeared when the treatment was stopped. Stibiointoxication cases, mainly acute renal failure, were serious.

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