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. 2005 Apr;45(8):991-1002.
doi: 10.1016/j.visres.2004.10.022. Epub 2004 Dec 2.

Responses of Müller glia to retinal injury in adult zebrafish

Patrick Yurco  1 , David A Cameron
Affiliations
Free article

Responses of Müller glia to retinal injury in adult zebrafish

Patrick Yurco et al. Vision Res. 2005 Apr.
Free article

Abstract

In an effort to identify the cellular events that enable neuronal regeneration in the vertebrate retina, the identity and characteristics of mitotic and apoptotic cells were examined in lesioned retinas of adult zebrafish. Following lesion a complex spatiotemporal pattern of mitosis was observed, including a delayed entry of Müller glia into the cell cycle. Characteristics of these proliferative Müller glia indicated they might serve as a stem/precursor cell of regenerated retina. The results suggested a model of retinal regeneration in which lesions are filled, in part, by a localized en place cytogenesis within intact retina surrounding the lesion site.

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