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. 2005 Feb;43(2):745-9.
doi: 10.1128/JCM.43.2.745-749.2005.

High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania

Bjørn Blomberg  1 , Roland Jureen, Karim P Manji, Bushir S Tamim, Davis S M Mwakagile, Willy K Urassa, Maulidi Fataki, Viola Msangi, Marit G Tellevik, Samwel Y Maselle, Nina Langeland
Affiliations

High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania

Bjørn Blomberg et al. J Clin Microbiol. 2005 Feb.

Abstract

Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.

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Figures

FIG. 1.
FIG. 1.
AFLP dendrogram of ESBL-producing bacterial isolates as evaluated by Pearson and UPGMA analysis. The diagram also shows the TEM, SHV, and CTX-M genotypes of the isolates and the MICs of ceftazidime, cefotaxime, and cefepime with or without clavulanate by using the ESBL Etest. -, Not detected; ND, no data.
FIG. 2.
FIG. 2.
Survival time (in days) after admission to the hospital of children with septicemia caused by E. coli, Klebsiella spp., or salmonellae with or without ESBL. Lines: solid, children with septicemia caused by ESBL-producing bacteria; dashed, children with septicemia caused by non-ESBL-producing bacteria.
FIG. 3.
FIG. 3.
Survival time (in days) after admission to the hospital of children with septicemia caused by E. coli, Klebsiella spp., or salmonellae with or without ESBL. Lines: solid, children with septicemia caused by ESBL-producing bacteria; dashed, children with septicemia caused by bacteria that did not have an ESBL phenotype but were resistant to the given antimicrobial chemotherapy due to other mechanisms.
See this image and copyright information in PMC

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