Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity
- PMID: 15698860
- DOI: 10.1016/j.lfs.2004.09.028
Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity
Abstract
Efficacy of chemotherapy may be maximized and its toxicity can be minimized if drugs would be administered at specified daily times. The present study was aimed to examine if the protection of amifostine against cisplatin toxicity is time dependent. Amifostine is an organic thiophosphate that protects selectively normal tissues, but not tumors, against the cytotoxicity of DNA binding chemotherapeutic agents such as cisplatin. ICR male mice which were entrained to Light:Dark (L:D) 14:10 were injected (intrapritoneal bolus) for 5 consecutive days with either: cisplatin, cisplatin plus amifostine (administered 30 minutes prior to cisplatin). Injections were given at either 08:00, 13:00, 20:00 or 01:00. Five days later, on day 10, each set of mice was sacrificed (at the same hour corresponds to the injection hour), blood count, blood creatinine and blood urea nitrogen (BUN) were assayed. Cisplatin treated mice exhibited nephrotoxicity, as indicated by increased blood urea nitrogen values and by high blood urea nitrogen to creatinine ratios, as well as myelotoxicity that was indicated by low levels of hemoglobin and platelets. Co-administration of amifostine-cisplatin reversed both, the nephrotoxicity of cisplatin, and its myelosuppressive effects. For BUN, hemoglobin and platelets, maximal protections were observed at 08:00, (p <0.05, p <0.01 and p <0.01 respectively). For BUN/Cr ratio (p <0.05), maximal protections was observed at 13:00. These findings show that amifostine exhibits time dependent protection against cisplatin toxicity and thus it is recommended to use the protector when treatments are given during morning hours. The results also further validate the notion that chronochemotherapy is advantageous at least in reducing drug toxicity and thus should be integrated in the design of clinical protocols.
Similar articles
-
Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.Cancer Res. 1990 Nov 1;50(21):7031-6. Cancer Res. 1990. PMID: 2208170
-
Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice.Phytother Res. 2009 Jul;23(7):999-1005. doi: 10.1002/ptr.2740. Phytother Res. 2009. PMID: 19140122
-
Amifostine reduces the incidence of cumulative nephrotoxicity from cisplatin: laboratory and clinical aspects.Semin Oncol. 1999 Apr;26(2 Suppl 7):72-81. Semin Oncol. 1999. PMID: 10348264 Review.
-
The influence of active hexose correlated compound (AHCC) on cisplatin-evoked chemotherapeutic and side effects in tumor-bearing mice.Toxicol Appl Pharmacol. 2007 Jul 15;222(2):152-8. doi: 10.1016/j.taap.2007.03.031. Epub 2007 Apr 20. Toxicol Appl Pharmacol. 2007. PMID: 17555784
-
The potential of amifostine: from cytoprotectant to therapeutic agent.Haematologica. 1999 Nov;84(11):1035-42. Haematologica. 1999. PMID: 10553165 Review.
Cited by
-
Sex Difference in Cisplatin-Induced Nephrotoxicity: Laboratory and Clinical Findings.J Toxicol. 2022 Oct 10;2022:3507721. doi: 10.1155/2022/3507721. eCollection 2022. J Toxicol. 2022. PMID: 36263084 Free PMC article. Review.
-
Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents.Neoplasia. 2013 May;15(5):523-34. doi: 10.1593/neo.13142. Neoplasia. 2013. PMID: 23633924 Free PMC article.
-
Protective Effect of D-Methionine on Body Weight Loss, Anorexia, and Nephrotoxicity in Cisplatin-Induced Chronic Toxicity in Rats.Integr Cancer Ther. 2018 Sep;17(3):813-824. doi: 10.1177/1534735417753543. Epub 2018 Feb 11. Integr Cancer Ther. 2018. PMID: 29430988 Free PMC article.
-
Encapsulation of cisplatin in long-circulating and pH-sensitive liposomes improves its antitumor effect and reduces acute toxicity.Int J Nanomedicine. 2012;7:5259-69. doi: 10.2147/IJN.S34652. Epub 2012 Oct 9. Int J Nanomedicine. 2012. PMID: 23091378 Free PMC article.
-
Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury.Naunyn Schmiedebergs Arch Pharmacol. 2018 Sep;391(9):915-931. doi: 10.1007/s00210-018-1514-4. Epub 2018 Jun 2. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29860655
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical