Bacterial toxins and the immune system: show me the in vivo targets
- PMID: 15699067
- PMCID: PMC2213035
- DOI: 10.1084/jem.20050080
Bacterial toxins and the immune system: show me the in vivo targets
Abstract
Microorganisms that cause persistent infection often exhibit specific adaptations that allow them to avoid the adaptive immune response. Recently, several bacterial toxins have been shown in vitro to disrupt immune cell functions. However, it remains to be established whether these activities are relevant during infection and whether these toxins have specifically evolved to disrupt the adaptive immune system.
Comment on
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Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling.J Exp Med. 2005 Feb 7;201(3):325-31. doi: 10.1084/jem.20041557. J Exp Med. 2005. PMID: 15699068 Free PMC article.
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The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation.J Exp Med. 2005 Feb 7;201(3):361-71. doi: 10.1084/jem.20041120. J Exp Med. 2005. PMID: 15699071 Free PMC article.
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