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Comparative Study
. 2005 Feb;97(2):299-302.
doi: 10.1254/jphs.sc0040146. Epub 2005 Feb 5.

Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells

Masakazu Ishii  1 , Shunichi Shimizu, Teruaki Wajima, Tamio Hagiwara, Takaharu Negoro, Akira Miyazaki, Takashi Tobe, Yuji Kiuchi
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Free article
Comparative Study

Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells

Masakazu Ishii et al. J Pharmacol Sci. 2005 Feb.
Free article

Abstract

We examined the effect of H(2)O(2) on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition of H(2)O(2) to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH(4)) content and GTPCH mRNA levels. The inhibitors of nitric oxide (NO) synthase and GTPCH had no influence on the decrease of GFRP mRNA levels in H(2)O(2)-treated cells. It is suggested that H(2)O(2) induces BH(4) synthesis through not only induction of GTPCH but also reduction of GFRP. The decrease of GFRP mRNA level appears to be independent of the produced NO and BH(4).

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